аЯрЁБс>ўџ 57ўџџџ4џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅСq` јRПbjbjqPqP2":: џџџџџџЄ№№№№№№№    $0 m*H”ммммммм—hџB№є ммє є №№мм'   є Ц№м№м є   №№ м< š2жъўХ К  =0m Aа A  цA№ш (мL( 6 ^ ,Š jмммь мммmє є є є №№№№№№џџџџ Title: Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma Author(s):  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Zhang+WM&curr_doc=1/4&Form=FullRecordPage&doc=1/4" \o "one-click search" Zhang WM,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Lo+Muzio+L&curr_doc=1/4&Form=FullRecordPage&doc=1/4" \o "one-click search" Lo Muzio L,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Rubini+C&curr_doc=1/4&Form=FullRecordPage&doc=1/4" \o "one-click search" Rubini C,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Yan+G&curr_doc=1/4&Form=FullRecordPage&doc=1/4" \o "one-click search" Yan G Source: ONCOLOGY REPORTS 13 (6): 1095-1099 JUN 2005 Document Type: Article Language: English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=PagedCitedRefList&UT=000229057300014&doc=1/4&rec_id=144273289" Cited References: 42      Times Cited: 0      HYPERLINK "Weimin%20Zhang2005.pdf" \t "_blank" INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/Links/WOK3/Generic_Src.gif" \* MERGEFORMATINET  Abstract: WNT-1 has been demonstrated to play an important role in the carcinogenesis of some cancers, but its significance in oral squamous cell carcinoma (OSCC) has not yet been elucidated. We investigated the WNT-1 expression in OSCC, its role on the expression of B-catenin and its relation to Ki-67 and tumor differentiation. Surgical specimens from 82 OSCC patients were examined for WNT-1, B-catenin, E-cadherin, γ-catenin and Ki-67 expression by irnmunohistochemical staining. The results were compared with the clinicopathological data and the relationships were correlated. WNT-1 expression was low in 39 cases, moderate in 5 cases, and high in 38 cases. WNT-1 showed a significant association with the expression of 13-catenin, E-cadherin, γ-catenin and Ki-67. It was significantly correlated with tumor differentiation. The results of this study showed that WNT-1 expression is correlated with B-catenin, Ki-67 and tumor differentiation, which suggested that WNT-1 might play an important role in the disturbed differentiation and uncontrolled proliferation during OSCC carcinogenesis. Author Keywords: WNT-1; catenin; cadherin; Ki-67; carcinogenesis; oral; squamous cell carcinoma; head and neck KeyWords Plus: E-CADHERIN; HEPATOCELLULAR CARCINOMAS; PROLIFERATIVE ACTIVITY; NUCLEAR ACCUMULATION; SIGNAL-TRANSDUCTION; PROGNOSTIC FACTOR; LOCALIZATION; PROGRESSION; ACTIVATION; ADHESION Addresses: Yan G (reprint author), Peking Univ, Coll Stomatol, Dept Oral Pathol, 22 Zhong Guan Cun St,Hai Dian Dist, Beijing, 100081 Peoples R China Peking Univ, Coll Stomatol, Dept Oral Pathol, Beijing, 100081 Peoples R China Univ Foggia, Dept Surg Sci, Foggia, Italy Univ Ancona, Inst Pathol, Ancona, Italy E-mail Addresses:  HYPERLINK "mailto:gaoyan1954@126.com" gaoyan1954@126.com Publisher: PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS 116 35, GREECE Subject Category: ONCOLOGY IDS Number: 925MN ISSN: 1021-335X …‡‘’“G H P Q S T     Э Ю ж з й к ‹ Œ ‘ ’ ” › œ Ќ Щ з с ъ є ѕ ƒ „ чаЖачаšаš€šаšаšišаšаšišаšаšišачаЖачачаšаš,hчxhчx>*B*CJKHOJQJ^Jphџ2hчxhчx5>*B*CJKHOJQJ\^Jphџ6jhчxhчxB*CJKHOJQJU^JaJph3hчxhчx5B*CJKHOJQJ\^JaJph-hчxhчxB*CJKHOJQJ^JaJph/hчxhчx5B*CJKHOJQJ\^Jph)‡” Щ с є h П/ь"rвюєєєєєыєєєєєєєєєщ $1$a$gdчx $1$9Da$gdчx§„ • ˜ ™ Ÿ Ћ В Х Ц є ѕ і цЯГœ‚œlWG,W4jhЕt4hЕt4B*CJOJQJUaJphџhЕt4B*CJOJQJaJphџ(jhу(ŒB*CJOJQJUaJphџ*hмAB*CJKHOJQJ^JaJo(ph3hчxhчx5B*CJKHOJQJ\^JaJph-hчxhчxB*CJKHOJQJ^JaJph6jhчxhчxB*CJKHOJQJU^JaJph,hчxhчx>*B*CJKHOJQJ^Jphџ2hчxhчx5>*B*CJKHOJQJ\^Jphџ і ї b c d e f h q ПЯ/=ьі"345\]opr|вуюљылыУыЎ——————c—cLc————,hчxhчx>*B*CJKHOJQJ^Jphџ6jhчxhчxB*CJKHOJQJU^JaJph/hчxhчx5B*CJKHOJQJ\^Jph-hчxhчxB*CJKHOJQJ^JaJph(jhу(ŒB*CJOJQJUaJphџ.jмhЈrђhмAB*CJOJQJUaJphџhмAB*CJOJQJaJphџ(jhмAB*CJOJQJUaJphџчаЫ hчxo(-hчxhчxB*CJKHOJQJ^JaJph/hчxhчx5B*CJKHOJQJ\^Jph0182PА‚. 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